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Clenbuterol

MECHANISM OF ACTION

Clenbuterol Mechanism of Action

Clenbuterol Hydrochloride

Chemical Name: 1-4-Amino-3,5-dichlorophenyl)-2-tert-butyl aminoethanol HCl. Also known as Ventipulmin

Molecular Weight of Base: 277.193

Dose : 80-160 mcg per day (see Clenbterol Dosage information)



Clenbuterol is a sympathomimetic and is a beta-2-adrenergic agonist in fat and muscle tissue with properties similar to adrenaline. Sympathomimetics are a class of drugs whose effects mimic stimulation of the sympathetic nervous system. Leading to

 

  • Increased Cardiac Output (more blood being pumped out by heart at each beat)
  • Relaxes smooth muscle in the bronchial tree of the lungs to act as a bronchodilator which increases the amount of oxygen available to be diffused into the blood stream. Therefore more oxygen is available to muscles which can result in strength gains. (NOTE: strength gains are effective only for about 3-4 weeks as it is caused by Clenbuterol’s stimulant effect rather than an anabolic effect)
  • Blood Pressure rises
  • Fat and protein loss increases (due to increased metabolic rate fat cells are stimulated to accelerate the breakdown of triglycerides into free fatty acids.) This leads to loss of adipose tissue leading in turn to a leaner physique with cuts and striations.
  • Slows down the storage of glycogen by reversing the effects of insulin and inhibiting the action of insulin, making more glucose available to be used as an energy source together with the increased oxygen.
  • It is also tocolytic and suppresses contractions (e.g. to prevent premature labour although not generally used for this)
  • Increased thermogenesis (creation of heat) leading to a higher body temperature

Higher body temperature attained by burning more glucose which is obtained from brown fat.

  • Alters the contractile characteristics of smooth muscle but very specifically – some are stimulated and some inhibited.

The effects are similar to ephedrine (a banned drug in sports) and Ma Huang but the effects are more potent and longer lasting as a stimulant and thermogenic drug.


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